100+ Grey's Anatomy Trivia Questions with Answers to Test Even the Biggest Fans

I’ve been obsessed with Grey’s Anatomy since the very first episode aired, and let me tell you, nothing brings my friends together quite like testing our knowledge of Seattle Grace (or Grey Sloan Memorial, depending on which season you’re on!). I’ve put together this collection of 100+ Grey’s Anatomy trivia questions that range from easy to “only the die-hards will know this” difficult.

Last month, I hosted a Grey ‘s-themed viewing party for the season finale, and these questions turned what could have been just another watch party into an unforgettable night of laughs, gasps, and “I can’t believe you remembered that!” moments. Whether you’re planning a themed party, looking for a way to pass time with fellow fans, or just want to test your own knowledge, these questions have got you covered!

General Grey’s Anatomy Trivia

Let’s start with some general questions that cover the basics of the show. These range from easy facts that casual viewers might know to some detailed questions for the superfans. I’ve found these are great warm-up questions before getting into the more specific categories!

What is the name of the hospital where the show primarily takes place? Answer: Grey Sloan Memorial Hospital (previously Seattle Grace Hospital, then Seattle Grace Mercy West Hospital)
In which year did Grey’s Anatomy first premiere? Answer: 2005
Who created Grey’s Anatomy? Answer: Shonda Rhimes

What is the name of the bar where the doctors often go after work? Answer: Joe’s Bar (or Emerald City Bar)
What was Meredith’s mother’s name? Answer: Ellis Grey
What is the hospital’s original name before it became Grey Sloan Memorial? Answer: Seattle Grace Mercy West Hospital

What does “007” refer to in the first season? Answer: George O’Malley’s nickname meaning “Licensed to Kill” because he failed his first surgery
Which character narrated most of the episodes in the early seasons? Answer: Meredith Grey
What is the name of the Chief of Surgery in Season 1? Answer: Richard Webber

What color are the intern scrubs? Answer: Light blue
What does “Code Black” mean in the hospital? Answer: There’s a bomb in the hospital
Which Seattle hospital merged with Seattle Grace? Answer: Mercy West

Which attending was nicknamed “The Nazi” in early seasons? Answer: Dr. Miranda Bailey
What was the name of the documentary crew that filmed at the hospital after the shooting? Answer: Seattle Medical: Road to Recovery
What natural disaster hit Seattle in Season 9? Answer: Superstorm

What specialty did Meredith Grey choose? Answer: General Surgery
What was the original title of the show before it became “Grey’s Anatomy”? Answer: Complications
What is Seattle Grace’s ranking among teaching hospitals when the series begins? Answer: #2 teaching hospital in the country

What catastrophic event happened at the end of Season 3? Answer: Meredith nearly drowning
Which character declares themselves to be “the Chief’s secret weapon” in the pilot episode? Answer: Miranda Bailey

If you enjoy testing your knowledge about your favorite shows, you might also like these video game trivia questions for another fun activity with friends!

Character-Specific Trivia

The characters are what make Grey’s Anatomy so special! From their quirky habits to their heartbreaking backstories, let’s see how well you know the doctors who’ve walked the halls of Seattle Grace/Grey Sloan Memorial. My friends always get super competitive over this section—everyone has their favorite character they want to prove they know best!

What is Meredith Grey’s middle name? Answer: Elizabeth
Where did Cristina Yang attend medical school? Answer: Stanford

What was Alex Karev’s original specialty before switching to pediatrics? Answer: Plastic surgery
What disease does Richard Webber’s wife, Adele, develop? Answer: Alzheimer’s
What is Derek Shepherd’s signature procedure? Answer: Shepherd Method for treating inoperable brain tumors

Which character has a pet ferret named Boki? Answer: George O’Malley
What is Arizona Robbins’ middle name? Answer: Marie
Which resident is known as “Evil Spawn”? Answer: Alex Karev

What was Miranda Bailey’s childhood nickname? Answer: Mandy
Which character has a photographic memory? Answer: Lexie Grey
What country was Teddy Altman stationed in with Owen Hunt? Answer: Iraq

What instrument does Owen Hunt use to calm himself down? Answer: A vent in the hospital basement
What is Jackson Avery’s mother’s name and position? Answer: Catherine Fox (formerly Avery), urologist and head of the Fox Foundation
What was Izzie Stevens’ career before becoming a doctor? Answer: Model (specifically for underwear, earning the nickname “Dr. Model”)

Which doctor was nicknamed “McSteamy”? Answer: Mark Sloan
What is Callie Torres’ full name? Answer: Calliope Iphegenia Torres
Which character has a fear of flying? Answer: Meredith Grey

What was April Kepner’s childhood nickname on the farm? Answer: Duckie
Who has a tattoo of a butterfly on their pelvis? Answer: Lexie Grey
What does the “M” in Amelia Shepherd’s middle name stand for? Answer: Margaret

Which character says “It’s a beautiful day to save lives” before surgeries? Answer: Derek Shepherd
What is Jo Wilson’s birth name? Answer: Brooke Stadler
Which doctor wears “lucky” red scrub caps? Answer: April Kepner

What tattoo does Meredith get after the plane crash? Answer: A simple outline of a heart on her wrist
Which character had a brain tumor that caused them to see their dead fiancée? Answer: Izzie Stevens

Looking for more personal questions to deepen your connections? Try these deep questions to ask a girl for meaningful conversations!

Medical Cases and Procedures

What’s Grey’s Anatomy without the medicine? These questions focus on the wild, weird, and wonderful medical cases that have kept us on the edge of our seats. I still get chills thinking about some of these groundbreaking surgeries and bizarre patient situations!

What rare surgery did Derek and Burke perform together in Season 2? Answer: Stand-still surgery (where they stop a patient’s heart and circulation)
What was lodged in the body of the “train crash guy” paired with Bonnie? Answer: A pole

What condition did the quint babies have that required surgery? Answer: Spina bifida
What did Meredith and Derek use to remove a tumor from a patient’s brain in an early clinical trial? Answer: Virus-injected cells that would target the tumor
What was the name of the conjoined twins that were separated in Season 2? Answer: Jake and Pete Weitzman

What animal attacked a patient prompting Derek to say “It’s a beautiful day to save lives” for the first time? Answer: A lion
What organ did Izzie cut through while trying to save the deer? Answer: The deer’s carotid artery
What happens to the man with the tree growing in his lung? Answer: Dr. Webber successfully removes it

What was unique about the clinical trial that Meredith and Derek worked on? Answer: It focused on using a virus to treat inoperable brain tumors
What caused the “toxic patient” emergency that affected multiple doctors? Answer: A toxic blood sample that released paralyzing fumes
What medical condition required Meredith to perform a surgery using only a clipboard light? Answer: Burst aneurysm during a blackout

What was in the patient who exploded in the OR? Answer: Ammunition/bullets that exploded due to the cauterizer
What rare procedure did Arizona and Herman perform on an unborn baby? Answer: In-utero spina bifida repair
What disease did Catherine Avery diagnose Richard with when everyone thought he had Alzheimer’s? Answer: Cobalt poisoning from his hip replacement

What type of surgery does Jo Wilson perform with a power drill during a storm? Answer: Burr hole (to relieve pressure on the brain)
What does Bailey name her bacterial infection discovery? Answer: Bailey Method
What was unique about Kai Bartley’s approach to Parkinson’s treatment? Answer: Using stem cells to treat the disease

What is the name of the procedure Derek and Callie develop together? Answer: Shepherd-Torres Method
What rare heart condition does Maggie diagnose in a family of patients? Answer: Familial Cardiomyopathy
What common object does Cristina use to fix a patient’s heart in the field during the plane crash? Answer: A drinking straw

For more brain teasers to challenge your friends, check out these math trivia questions that provide a different kind of mental workout!

Relationships and Romance

Grey’s Anatomy might be a medical drama, but let’s be honest—we’re all here for the romance too! These questions cover the many, many relationships that have formed (and often dramatically ended) at Seattle Grace/Grey Sloan Memorial. My roommate and I still argue about which couple was the best match!

What are the vows that Meredith and Derek wrote on a Post-it note? Answer: “To love each other even when we hate each other. No running. Take care when old, senile, and smelly. And it’s forever.”

Who did Cristina Yang marry first? Answer: Preston Burke
What does Mark Sloan call Lexie in his dying moments? Answer: “Little Grey”
Which couple got married on a post-it note before having an official wedding? Answer: Meredith Grey and Derek Shepherd

Who interrupted April’s wedding to Matthew? Answer: Jackson Avery
Which doctor did Teddy marry for insurance purposes? Answer: Henry Burton
Which character declares “Pick me, choose me, love me”? Answer: Meredith Grey to Derek

What was the name of Alex Karev’s first wife? Answer: Izzie Stevens
Which resident did Attendee Mark Sloan date breaking the “no dating residents” rule? Answer: Lexie Grey
Where did Callie and Arizona get married? Answer: In a forest/outdoor ceremony

Who does Owen Hunt marry after Cristina leaves? Answer: Amelia Shepherd
What was written on the scrub cap that Derek gave to Meredith? Answer: “Property of Meredith Grey”
What song played during Meredith and Derek’s first surgery together? Answer: “Like a Virgin” by Madonna

Which doctor did Arizona cheat on Callie with during the storm? Answer: Dr. Lauren Boswell
Who was Alex’s final love interest on the show? Answer: Jo Wilson
What did Maggie and Winston use instead of rings at their wedding? Answer: Sutures tied around each other’s fingers

What location is significant to Ben and Bailey’s relationship? Answer: The hospital boiler room (where Ben proposed)
Which couple had a wedding ceremony in a barn? Answer: April Kepner and Matthew Taylor (second wedding)
What does Cristina give to Meredith before leaving for Switzerland? Answer: Her shares of the hospital and “her” person (Alex)

Which doctor leaves his wife via a note? Answer: Alex Karev

Want to dive deeper into relationship questions? Try these questions for couples to strengthen your own connection!

Behind the Scenes

Let’s go beyond what happens on screen and test your knowledge of cast facts, production details, and interesting tidbits about the making of Grey’s Anatomy. I’m always fascinated by the real-life stories behind my favorite shows!

Which actor was originally cast to play Derek Shepherd before Patrick Dempsey? Answer: Rob Lowe
Which cast member directed several episodes of the show? Answer: Chandra Wilson (Miranda Bailey)
Which actress was pregnant during filming, causing her character to be sent to Africa? Answer: Jessica Capshaw (Arizona Robbins)

What is the name of Ellen Pompeo’s first child, who made a cameo appearance on the show? Answer: Stella Luna
Which Grey’s actor previously starred in another medical drama, “St. Elsewhere”? Answer: Eric Dane (Mark Sloan)
What real-life doctor serves as the show’s medical consultant? Answer: Dr. Zoanne Clack

Which Grey’s Anatomy spin-off featured Kate Walsh as the main character? Answer: Private Practice
Which cast member was discovered by Shonda Rhimes while working as a waiter? Answer: Justin Chambers (Alex Karev)
Which actress originally auditioned for the role of Miranda Bailey? Answer: Sandra Oh (who eventually played Cristina Yang)

What was the original character name for Miranda Bailey before it was changed? Answer: Helen Rubenstein
Which actress left the show to star in her own Shonda Rhimes series? Answer: Sandra Oh
How many episodes did Katherine Heigl’s character appear in before leaving? Answer: 120 episodes

Which real-life spouses both appeared on Grey’s Anatomy? Answer: Kevin McKidd (Owen Hunt) and Arielle Goldrath
What was the production code name used for Grey’s Anatomy during its initial filming? Answer: “Surgeons”
Which Grey’s actress won an Emmy for her role in the show? Answer: Katherine Heigl

How many Emmy nominations has the show received in total? Answer: Over 35 Emmy nominations
Which Grey’s actor voices a character in the video game Mass Effect? Answer: Seth Green (who played Nick)
What is the significance of the 100th episode of Grey’s Anatomy? Answer: It featured George O’Malley’s funeral and Izzie’s cancer surgery

Which actress was written off the show after refusing to come back and film a proper exit? Answer: Katherine Heigl
What is the name of the documentary web series that gives behind-the-scenes looks at Grey’s Anatomy? Answer: “Post-Op”

For more entertainment trivia, check out these 90s movie trivia questions that will bring back nostalgic memories!

Why Grey’s Anatomy Trivia is Perfect for Fans

If you’re anything like me, you’ve spent countless hours invested in the lives of the doctors at Grey Sloan Memorial. Grey’s Anatomy trivia isn’t just fun—it’s a way to celebrate all those emotional moments, shocking twists, and unforgettable characters that have kept us watching for years.

I’ve found that Grey’s trivia is perfect for bringing together fans of all levels. My sister only started watching in season 10, while I’ve been there since day one, but we can both enjoy competing to see who remembers more details. Plus, there’s something incredibly satisfying about knowing exactly which intern ate their lunch on a dead person or remembering all of Cristina Yang’s best one-liners!

The show has given us so many iconic moments over the years that revisiting them through trivia feels like catching up with old friends. And trust me, nothing breaks the ice at a party faster than debating whether McDreamy or McSteamy was the better nickname!

Need more conversation starters beyond TV shows? Check out these interesting topics to talk about for your next get-together!

Final Thoughts

Whew! How did you do? Whether you aced these questions or discovered some Grey’s Anatomy facts you never knew before, I hope this trivia brought back some great memories of the show we all love.

My friends and I have spent countless evenings debating whether “McDreamy” or “McSteamy” was the better nickname and re-watching those classic episodes that made us laugh, cry, and sometimes throw things at the TV! These trivia questions are perfect for your next watch party, virtual hangout, or just to test your own Grey’s knowledge while waiting for the next season.

Did you know all the answers? Which section was the easiest or hardest for you? I’d love to know which character you think had the best storyline throughout the series!

If you enjoyed this Grey’s Anatomy trivia, you might also want to check out our other TV show trivia collections or our philosophical questions that might make you think as deeply as Meredith’s voiceovers do!

Now, in the immortal words of Miranda Bailey: “The game is over. I’m Dr. Bailey. I know everything.” Do you?